Innovations in pharmaceutical product development
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Innovations in pharmaceutical product development 〰️
Artificial Intelligence (AI) Applications in Drug Discovery and Drug Delivery: Revolutionizing Personalized Medicine
Dolores R Serrano, Francis C Luciano, Brayan J Anaya, Baris Ongoren, Aytug Kara, Gracia Molina, Bianca I Ramirez, Sergio A Sánchez-Guirales, Jesus A Simon, Greta Tomietto, Chrysi Rapti, Helga K Ruiz, Satyavati Rawat, Dinesh Kumar, Aikaterini Lalatsa. Pharmaceutics, 16, 10, 2024. Doi: harmaceutics16101328
Stability of meropenem in portable elastomeric infusion devices: which protocol should be implemented in clinical practice?
Beatriz Esteban-Cartelle, Dolores R Serrano, Covadonga Pérez Menéndez-Conde, Noelia Vicente-Oliveros, Ana Álvarez-Díaz, Jesús Fortún Abete, Pilar Martín-Dávila. Microbiology Spectrum, 12, 1, 2024. Doi: 10.1128/spectrum.02064-23
Mental health and drug use in college students: Should we take an action?
Teresa Pérez, M Carmen Pardo, Yolanda Cabellos, Melina Peressini, Isabel Ureña-Vacas, Dolores R Serrano, Elena González-Burgos. Journal of Affective Disorders, 338, 32-40, 2023. Doi: 10.1016/j.jad.2023.05.080
Melatonin as modulator for sulfur and nitrogen mustard-induces inflammation, oxidative stress and DNA damage: Molecular therapeutics
Eva Ramos, Emilio Gil-Martín, Cristóbal De Los Ríos, Javier Egea, Francisco López-Muñoz, René Pita, Antonio Juberías, Juan J Torrado, Dolores R Serrano, Russel J Reiter, Alejandro Romero. Antioxidants 12 (2), 397. 2023. Doi: 10.3390/antiox12020397
Guiding Clinical Prescription of Topical Extemporaneous Formulations of Sodium Cromo Glycate Based on Pharmaceutical Performance
Olga González-González, Enrique Leal, Mercedes Martín-Martínez, Liliana Bautista, Maria Paloma Ballesteros, Juan J Torrado, Dolores R Serrano. Pharmaceutics 15 (6), 1609, 2023. doi: 10.3390/pharmaceutics15061609
Current Treatments for COVID-19: Application of Supercritical Fluids in the Manufacturing of Oral and Pulmonary Formulations
Helga K Ruiz, Dolores R Serrano, Lourdes Calvo, Albertina Cabañas. Pharmaceutics, 2022.
Drug Stability: ICH versus Accelerated Predictive Stability Studies
Olga González-González, Irving O Ramirez, Bianca I Ramirez, Peter O’Connell, Maria Paloma Ballesteros, Juan José Torrado, Dolores R Serrano. Pharmaceutics, 2022.
Continuous Manufacturing and Molecular Modeling of Pharmaceutical Amorphous Solid Dispersions
Amritha G Nambiar, Maan Singh, Abhishek R Mali, Dolores R Serrano, Rajnish Kumar, Anne Marie Healy, Ashish Kumar Agrawal, Dinesh Kumar. AAPS PharmSciTech. 2022.
Effect of Primary Packaging Material on the Stability Characteristics of Diazepam and Midazolam Parenteral Formulations
María José Rodríguez Fernández, Dolores Remedios Serrano Lopez, Juan José Torrado. Pharmaceutics, 2022.
Antibiotic stability in portable elastomeric infusion devices: A systematic review
Beatriz Esteban-Cartelle, Noelia Vicente-Oliveros, Covadonga Pérez Menéndez-Conde, Dolores R. Serrano, Pilar Martín-Dávila, Jesús Fortún-Abete, Lourdes A. León-Gil, Ana Álvarez-Díaz. Am J Health Syst Pharm, 2022. DOI: 10.1093/ajhp/zxac122
Tailoring Rational Manufacturing of Extemporaneous Compounding Oral Dosage Formulations with a Low Dose of Minoxidil
Carlos Torrado-Salmerón, Almudena Laguna, Alicia Guillén, MIgeul G. Saro, Antonio Matji, Juan J- Torrado, Dolores Serrano. Pharmaceutics. 2022. https://doi.org/10.3390/pharmaceutics14030658
Effect of Enantiomerism on the Bioequivalence of a New Ibuprofen 600-mg Tablet Formulation Obtained by Roller Compaction
Matji A, Vargas E, Carvajal L, Terleira AI, Portolés A, Garcia-Arieta A, Torrado JJ, Serrano DR. Chirality. 2019 Nov 22. doi: 10.1002/chir.23148
Predicting the critical quality attributes of ibuprofen tablets via modelling of process parameters for roller compaction and tabletting
Matji A, Donato N, Gagol A, Morales E, Carvajal L, Serrano DR, Worku ZA, Healy AM, Torrado JJ. Int J Pharm. 2019 Jun 30;565:209-218. doi: 10.1016/j.ijpharm.2019.05.011
Tuning the Transdermal Delivery of Hydroquinone upon Formulation with Novel Permeation Enhancers
Serrano DR, Gordo MJ, Matji A, González S, Lalatsa A, Torrado JJ. Pharmaceutics. 2019 Apr 4;11(4). pii: E167. doi: 10.3390/pharmaceutics11040167
A multivariate investigation into the relationship between pharmaceutical characteristics and patient preferences of bioequivalent ibuprofen tablets
Alonso TR, Gagol A, Scherer M, Matji A, Torrado-Santiago S, Serrano DR, Garcia-Arieta A, Torrado JJ. Patient Prefer Adherence. 2018 Sep 26;12:1927-1935. doi: 10.2147/PPA.S174479
Engineering of pharmaceutical cocrystals in an excipient matrix: Spray drying versus hot melt extrusion
Walsh D, Serrano DR, Worku ZA, Madi AM, O'Connell P, Twamley B, Healy AM. Int J Pharm. 2018 Nov 15;551(1-2):241-256. doi: 10.1016/j.ijpharm.2018.09.029
Drug Delivery Nanosystems for the Localized Treatment of Glioblastoma Multiforme
Nam L, Coll C, Erthal LCS, de la Torre C, Serrano D, Martínez-Máñez R, Santos-Martínez MJ, Ruiz-Hernández E. Materials (Basel). 2018 May 11;11(5). pii: E779. doi: 10.3390/ma11050779
Production of cocrystals in an excipient matrix by spray drying
Walsh D, Serrano DR, Worku ZA, Norris BA, Healy AM. Int J Pharm. 2018 Jan 30;536(1):467-477. doi: 10.1016/j.ijpharm.2017.12.020
Optimising the in vitro and in vivo performance of oral cocrystal formulations via spray coating
Serrano DR, Walsh D, O'Connell P, Mugheirbi NA, Worku ZA, Bolas-Fernandez F, Galiana C, Dea-Ayuela MA, Healy AM. Eur J Pharm Biopharm. 2018 Mar;124:13-27. doi: 10.1016/j.ejpb.2017.11.015
Effect of the characteristics of raw material ibuprofen on roller compaction and dissolution
Matji Antonio, Carvajal Luis, Conde Fernando, Peña María Angeles, Donato Nicoletto, Serrano Dolores R, TorradoJ.J. J Drug Deliv Sci Technol. 2017 Aug;42:237-244 doi:10.1016/j.jddst.2017.03.020
Analgesic and anti-inflammatory controlled-released injectable microemulsion: Pseudo-ternary phase diagrams, in vitro, ex vivo and in vivo evaluation
Pineros I, Slowing K, Serrano DR, de Pablo E, Ballesteros MP. Eur J Pharm Sci. 2017 Apr 1;101:220-227. doi: 10.1016/j.ejps.2016.12.030
Impact of Substrate Properties on the Formation of Spherulitic Films: A Case Study of Salbutamol Sulfate
Dolores R. Serrano, Naila A. Mugheirbi, Peter O’Connell, Neal Leddy, Anne Marie Healy, and Lidia Tajber Crystal Growth & Design 2016 16 (7), 3853-3858 DOI: 10.1021/acs.cgd.6b00390
Lomustine Nanoparticles Enable Both Bone Marrow Sparing and High Brain Drug Levels - A Strategy for Brain Cancer Treatments
Fisusi FA, Siew A, Chooi KW, Okubanjo O, Garrett N, Lalatsa K, Serrano D, Summers I, Moger J, Stapleton P, Satchi-Fainaro R, Schätzlein AG, Uchegbu IF. Pharm Res. 2016 May;33(5):1289-303. doi: 10.1007/s11095-016-1872-x
Modelling and shadowgraph imaging of cocrystal dissolution and assessment of in vitro antimicrobial activity for sulfadimidine/4-aminosalicylic acid cocrystals
Serrano DR, Persoons T, D'Arcy DM, Galiana C, Dea-Ayuela MA, Healy AM. Eur J Pharm Sci. 2016 Jun 30;89:125-36. doi: 10.1016/j.ejps.2016.04.030
Cocrystal habit engineering to improve drug dissolution and alter derived powder properties
Serrano DR, O'Connell P, Paluch KJ, Walsh D, Healy AM. J Pharm Pharmacol. 2016 May;68(5):665-77. doi: 10.1111/jphp.12476
Polymorphism in sulfadimidine/4-aminosalicylic acid cocrystals: solid-state characterization and physicochemical properties
Grossjohann C, Serrano DR, Paluch KJ, O'Connell P, Vella-Zarb L, Manesiotis P, Mccabe T, Tajber L, Corrigan OI, Healy AM. J Pharm Sci. 2015 Apr;104(4):1385-98. doi: 10.1002/jps.24345
Peptide pills for brain diseases? Reality and future perspectives
Serrano Lopez DR, Lalatsa A. Ther Deliv. 2013 Apr;4(4):479-501. doi: 10.4155/tde.13.5
The influence of CYP2C19 genetic polymorphism on the pharmacokinetics/- pharmacodynamics of proton pump inhibitor-containing Helicobacter pylori treatments
Serrano D, Torrado S, Torrado-Santiago S, Gisbert JP. Curr Drug Metab. 2012 Nov;13(9):1303-12 doi : 10.2174/138920012803341393